The exact cause of ARMS is not fully understood, but it is believed to be associated with genetic mutations. In most cases, a specific chromosomal translocation between chromosomes 2 and 13 or 1 and 13 is identified. This translocation results in the fusion of the PAX3 or PAX7 genes with the FKHR gene (also known as FOXO1), which plays a crucial role in the development of ARMS.
