Chemotherapy: Certain chemotherapy drugs can irritate the lining of the intestines. Radiation Therapy: Radiation to the abdominal or pelvic area can damage the intestines, leading to diarrhea. Surgery: Surgical procedures involving the digestive tract can alter bowel function. Infections: Cancer patients are more susceptible to infections that can cause diarrhea. Malabsorption: Some cancers and treatments can affect the absorption of nutrients.