What Challenges Exist in Targeting Apoptosis in Cancer?
Several challenges complicate the targeting of apoptosis in cancer therapy:
Resistance mechanisms: Cancer cells often develop resistance to apoptosis-inducing agents, necessitating combination therapies. Selective targeting: Ensuring that apoptosis is selectively induced in cancer cells without affecting normal cells is critical to minimize side effects. Tumor heterogeneity: The heterogeneous nature of tumors means that different cells within the same tumor may respond differently to apoptosis-inducing treatments.
