What Challenges Exist in Targeting Oxidative Stress in Cancer?
One of the main challenges is the dual role of ROS in cancer. While high levels of ROS can induce cancer cell death, moderate levels can promote cancer cell survival and proliferation. Therefore, achieving the right balance of ROS modulation is crucial. Additionally, the heterogeneous nature of tumors and the dynamic interplay between cancer cells and the tumor microenvironment complicate the development of effective oxidative stress-targeted therapies.
