ANRIL, short for Antisense Non-coding RNA in the INK4 Locus, is a long non-coding RNA (lncRNA) involved in the regulation of gene expression. It is transcribed from the INK4 locus, which also contains tumor suppressor genes such as p15INK4b, p16INK4a, and ARF. ANRIL plays a critical role in various cellular processes including proliferation, apoptosis, and senescence, making it a significant player in cancer biology.