CXCL12 is a chemokine that belongs to the CXC chemokine family, primarily expressed in stromal cells. It is known for its role in hematopoiesis, organogenesis, immune response, and particularly in cancer, where it facilitates tumor cell migration, survival, and proliferation. Its high-affinity receptor, CXCR4, is overexpressed in more than 20 types of human cancers, including breast, lung, and colorectal cancers.
