What is the Role of CXCL12 in the Tumor Microenvironment?
Within the tumor microenvironment, CXCL12 plays a multifaceted role. It recruits immune and endothelial cells to the tumor site, which can support angiogenesis and immune evasion. By promoting angiogenesis, CXCL12 ensures the tumor receives an adequate blood supply, facilitating its growth and dissemination. Furthermore, CXCL12 can modulate immune responses, often leading to an immunosuppressive environment that allows tumor cells to evade detection and destruction by the immune system.
