Hexokinase 2 (HK2) is an enzyme that plays a crucial role in the glycolytic pathway, catalyzing the first step of glycolysis: the conversion of glucose to glucose-6-phosphate. This enzyme is one of the four hexokinase isoforms (HK1, HK2, HK3, and HK4) found in mammalian tissues. HK2 is unique due to its high affinity for glucose and its regulatory capabilities, making it particularly important in tissues with high metabolic demands.
