Cancer cells typically undergo metabolic reprogramming to support rapid proliferation, a phenomenon known as the Warburg effect. In this metabolic state, cancer cells preferentially utilize glycolysis for energy production, even in the presence of sufficient oxygen. HK2 is often overexpressed in various types of cancer and contributes significantly to this metabolic shift by enhancing glycolysis and promoting anabolic processes. This overexpression supports the biosynthetic and energetic demands of rapidly dividing tumor cells.
