What is the Connection Between Mismatch Repair and Cancer?
Defects in MMR genes can lead to a condition known as Microsatellite Instability (MSI), which is characterized by hypermutability and a predisposition to Hereditary Nonpolyposis Colorectal Cancer (HNPCC), also known as Lynch Syndrome. Individuals with Lynch Syndrome have a higher risk of developing various types of cancer, particularly colorectal and endometrial cancers.
