Are There Any miRNA Inhibitors in Clinical Trials?
Several miRNA inhibitors are currently in preclinical and clinical development. For example, MRX34, a liposomal miR-34a mimic, was one of the first miRNA-based therapies to enter clinical trials for cancer treatment. Although the trial was halted due to immune-related adverse events, it highlighted the potential and challenges of miRNA-based therapies. Ongoing research aims to optimize these inhibitors and address safety concerns.