The ERCC1-XPF endonuclease complex is a crucial DNA repair enzyme that plays a significant role in maintaining genomic stability. This complex is composed of two proteins: ERCC1 (Excision Repair Cross-Complementation Group 1) and XPF (Xeroderma Pigmentosum group F). Together, they form a heterodimer that is essential for the nucleotide excision repair (NER) pathway, which is responsible for repairing bulky DNA adducts caused by UV radiation and chemical agents.
