Future research aims to better understand the intricate interactions between cancer cells and the ECM. Advances in imaging techniques and biomaterials are expected to provide deeper insights into ECM dynamics and its role in cancer progression. Moreover, the development of more sophisticated models, such as 3D culture systems and organ-on-a-chip technologies, will enhance our ability to study the ECM in a more physiologically relevant context. Ultimately, these efforts could lead to the identification of novel therapeutic targets and the development of more effective cancer treatments.