What is the Mechanism of Drug Resistance Associated with Thymidylate Synthase?
Cancer cells can develop resistance to TS inhibitors through various mechanisms. One common mechanism is the overexpression of TS itself, which reduces the effectiveness of drugs like 5-FU. Mutations in the TS gene can also alter the enzyme's structure, rendering inhibitors less effective. Additionally, changes in the folate pathway can affect the availability of cofactors required for TS inhibition, contributing to drug resistance.
