Thymidylate synthase (TS) is a key enzyme involved in the synthesis of thymidine monophosphate (dTMP), an essential precursor for DNA replication and repair. It catalyzes the conversion of deoxyuridine monophosphate (dUMP) to dTMP using 5,10-methylenetetrahydrofolate as a cofactor. Given its crucial role in DNA synthesis, TS is a target of several anticancer drugs, making it an important focus in cancer research.
