LKB1 is pivotal in regulating key cellular processes like metabolism, cell polarity, and apoptosis. Its activation of AMPK is particularly important during metabolic stress, as it helps restore energy balance by inhibiting anabolic processes and promoting catabolic processes. LKB1 also influences cell polarity and organization, which are critical for tissue architecture and function. Moreover, LKB1 can induce apoptosis in response to cellular damage, thereby preventing the survival of potentially cancerous cells.
