What is the Role of Mitochondrial Dynamics in Cancer?
Mitochondrial dynamics, including fission and fusion processes, are crucial for maintaining mitochondrial function and cellular homeostasis. Abnormal mitochondrial dynamics have been implicated in cancer. For instance, enhanced mitochondrial fission is associated with increased cell proliferation and resistance to apoptosis. Proteins such as Drp1 and Fis1 regulate mitochondrial fission, and their dysregulation can contribute to cancer progression. Conversely, mitochondrial fusion, regulated by proteins like Mfn1, Mfn2, and OPA1, is important for mitochondrial integrity and function.
