How Do Mitochondrial Mutations Contribute to Cancer?
Mutations in mitochondrial DNA (mtDNA) can affect mitochondrial function and contribute to cancer progression. These mutations can lead to defects in the electron transport chain, resulting in increased production of reactive oxygen species (ROS). Elevated ROS levels can cause DNA damage, promote genetic instability, and activate signaling pathways that favor cancer cell survival and proliferation. Additionally, some mtDNA mutations may confer a growth advantage to cancer cells by altering metabolic pathways.
