How Do Mitochondria Contribute to Cancer Metastasis?
Mitochondria play a role in cancer metastasis by influencing cell motility, invasion, and the adaptation to different microenvironments. Metastatic cancer cells often exhibit changes in mitochondrial function that support increased energy demands and resistance to stress. Mitochondrial biogenesis, the process of generating new mitochondria, is upregulated in metastatic cells to meet these demands. Additionally, mitochondria-derived ROS can enhance metastatic potential by promoting epithelial-to-mesenchymal transition (EMT) and modulating the tumor microenvironment.
