What Mechanisms Lead to Telomerase Activation in Cancer?
Multiple mechanisms can lead to the activation of telomerase in cancer cells:
Genetic Mutations: Mutations in the promoter region of the TERT gene can increase its expression. Epigenetic Changes: Alterations in DNA methylation and histone modification can lead to the upregulation of telomerase. Regulatory Proteins: Overexpression or activation of certain transcription factors can enhance TERT gene expression.
