Microtubules are essential for cell division, particularly during mitosis. They form the mitotic spindle, which segregates chromosomes into daughter cells. In cancer, microtubule dynamics are frequently disrupted, leading to chromosomal instability and aneuploidy, which are hallmarks of cancer. Additionally, microtubule-targeting agents, such as taxanes and vinca alkaloids, are commonly used chemotherapeutic drugs that disrupt microtubule function and inhibit cancer cell proliferation.
