What Role Do the Tumor Microenvironment and Extracellular Matrix Play?
The tumor microenvironment (TME) significantly influences cancer cell motility. The TME consists of various components, including stromal cells, immune cells, and the extracellular matrix (ECM). The ECM provides structural support and biochemical cues that can either promote or inhibit cancer cell migration. Enzymes like matrix metalloproteinases (MMPs) degrade the ECM, facilitating cancer cell invasion.
