What Role Does Cytosolic DNA Play in Cancer Progression?
Cytosolic DNA can activate innate immune responses within the cell. For instance, it can interact with pattern recognition receptors such as cGAS (cyclic GMP-AMP synthase), which then activates the STING pathway (Stimulator of Interferon Genes). This activation can lead to the production of type I interferons and other inflammatory cytokines, which can either suppress or promote cancer progression depending on the context.
