What Role Does Lactate Play in the Tumor Microenvironment?
Lactate can act as both a fuel source and a signaling molecule in the tumor microenvironment. It contributes to the acidic extracellular pH typical of tumors, which can promote invasion and metastasis. Additionally, lactate can be taken up by neighboring cells, including cancer-associated fibroblasts (CAFs) and immune cells, altering their metabolism and function. For instance, lactate uptake by CAFs can support the anabolic processes necessary for tumor growth.
