What Role Does the Spindle Apparatus Play in Cancer?
Cancer cells often exhibit abnormalities in the spindle apparatus, leading to aneuploidy—an abnormal number of chromosomes. These abnormalities can result from mutations in genes that regulate spindle function, allowing cancer cells to survive and proliferate despite chromosomal imbalances. Aberrant spindle apparatus function is a hallmark of many cancers and contributes to their progression and resistance to therapy.
