What are the Challenges in Targeting the Spindle Apparatus?
While targeting the spindle apparatus can be effective, it also poses challenges. Cancer cells may develop resistance to spindle-targeting drugs through various mechanisms, such as overexpression of drug efflux pumps or mutations in tubulin. Additionally, these drugs can affect normal dividing cells, leading to side effects such as neuropathy and myelosuppression. Thus, there is a need for more specific and less toxic therapeutic strategies.
