What Therapeutic Strategies Target Pro Apoptotic Proteins?
Several therapeutic strategies aim to modulate pro apoptotic proteins to treat cancer:
- BH3 Mimetics: These are small molecules that mimic the action of BH3-only proteins (a subset of pro apoptotic proteins). They bind to and inhibit anti apoptotic Bcl-2 family members, thereby promoting apoptosis in cancer cells. Venetoclax is a well-known BH3 mimetic used in the treatment of chronic lymphocytic leukemia. - Gene Therapy: Introducing genes encoding pro apoptotic proteins directly into cancer cells to trigger apoptosis. - Combination Therapies: Using pro apoptotic protein modulators in combination with other treatments like chemotherapy or radiotherapy to enhance cancer cell death.
