What Triggers the Vomiting Center in Cancer Patients?
Several triggers can activate the vomiting center in cancer patients:
Chemotherapy-Induced Nausea and Vomiting (CINV): Certain chemotherapy drugs are highly emetogenic, meaning they have a high likelihood of causing vomiting. These drugs can directly stimulate the CTZ, which in turn activates the vomiting center. Radiation Therapy: Radiation, especially to the abdomen or brain, can stimulate the vomiting center either directly or indirectly through the release of inflammatory cytokines. Tumor Location: Tumors in the gastrointestinal tract or brain can physically press on or irritate structures that send signals to the vomiting center. Metabolic Changes: Cancer can cause metabolic imbalances, such as hypercalcemia, that can trigger the vomiting center.
