GDNFs have been implicated in several types of cancers, including but not limited to:
- Breast Cancer: GDNF overexpression has been linked to increased metastatic potential. - Pancreatic Cancer: High levels of GDNF are associated with poor prognosis. - Prostate Cancer: GDNF signaling can promote androgen-independent growth. - Gliomas: Given their origin in glial cells, GDNFs are naturally of interest in glioma research.
