What Types of Chromosomal Rearrangements Are Common in Cancer?
Translocations: The exchange of segments between two chromosomes. This is commonly seen in cancers like chronic myeloid leukemia (CML) where the Philadelphia chromosome is formed. Deletions: The loss of a chromosome segment. Deletions can lead to the loss of tumor suppressor genes, contributing to cancer development. Duplications: The gain of an extra copy of a chromosome segment. This can result in the overexpression of oncogenes. Inversions: A chromosome segment is reversed end to end. This can disrupt gene function and regulation.
