Aggressive chemotherapy is typically considered in several scenarios: - When the cancer is in an __advanced stage__ and has spread to multiple parts of the body. - When the cancer is __high-grade__, meaning it grows and spreads quickly. - In cases of __relapsed__ or __refractory cancer__, where the disease has returned or does not respond to initial treatments. - Sometimes, it is used as part of a __high-dose chemotherapy__ with stem cell rescue, particularly in __hematologic cancers__ like __leukemia__ or __lymphoma__.
