Which Cancers Are Associated with EGFR Amplification?
EGFR amplification is observed in various cancers, most notably in non-small cell lung cancer (NSCLC), glioblastoma, and head and neck squamous cell carcinoma (HNSCC). In NSCLC, EGFR amplification frequently co-occurs with EGFR mutations and can influence treatment response. In glioblastoma, EGFR amplification is one of the most common genetic alterations and is associated with poor prognosis.
