How Does EGFR Amplification Impact Cancer Treatment?
The presence of EGFR amplification can influence the choice of targeted therapies. EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib and gefitinib, are often used to treat cancers with EGFR alterations. However, the efficacy of these treatments can be affected by the presence of additional mutations or resistance mechanisms. Understanding the specific genetic landscape of a tumor can help in tailoring personalized treatment strategies.
