Which Cancers are Most Affected by SWI/SNF Mutations?
Mutations in the SWI/SNF complex components are particularly prevalent in certain types of cancers, including ovarian cancer, lung cancer, and rhabdoid tumors. For instance, mutations in the SMARCB1 gene, a core subunit of the SWI/SNF complex, are almost universally present in malignant rhabdoid tumors.
