Which Genes are Commonly Affected by Nonsense Mutations in Cancer?
Certain genes are more frequently affected by nonsense mutations in cancer. These include key tumor suppressor genes like BRCA1 and BRCA2, which are associated with breast and ovarian cancers. Mutations in these genes can compromise DNA repair mechanisms, leading to increased mutation rates and cancer progression. Other notable genes include APC in colorectal cancer and PTEN in various cancers.
