Which Genes Are Commonly Affected by Promoter Hypermethylation in Cancer?
Several genes are known to undergo promoter hypermethylation in different cancers. Some of the commonly affected genes include:
BRCA1 - Associated with breast and ovarian cancers. MLH1 - Involved in DNA mismatch repair; hypermethylation is linked to colorectal cancer. RARB - Retinoic acid receptor beta, often methylated in various carcinomas. GSTP1 - Frequently hypermethylated in prostate cancer.
