The preference of certain cancers for specific organs is influenced by the characteristics of the target tissue. Factors such as blood supply, the presence of specific receptors, and the immune environment all play a role. For instance, breast cancer cells often metastasize to the lungs, liver, and bones. The microenvironment of these organs provides the necessary nutrients and signaling molecules that the cancer cells need to thrive. Understanding these preferences is essential for developing targeted therapies to prevent or treat metastatic cancer.