Why does the immune system sometimes fail to fight cancer?
Cancer cells can develop mechanisms to evade the immune system. They may downregulate the expression of antigens, secrete immunosuppressive molecules, or create an immunosuppressive tumor microenvironment. Additionally, cancer cells can express immune checkpoint proteins like PD-L1, which bind to receptors on T cells and inhibit their activity. These strategies enable cancer cells to avoid detection and destruction by the immune system.
