Historical controls can be particularly useful in cancer research for several reasons:
1. Ethical Concerns: In life-threatening conditions like cancer, it may be unethical to withhold a potentially beneficial new treatment from patients by placing them in a placebo group. 2. Rare Cancers: For rare cancers, recruiting enough participants for a randomized control trial (RCT) may be challenging. 3. Cost and Time Efficiency: Utilizing existing data can save time and resources, accelerating the process of bringing new treatments to market.
