Are there any challenges associated with miR-34a-based therapies?
Despite the potential of miR-34a-based therapies, several challenges need to be addressed. These include the efficient and targeted delivery of miR-34a to tumor cells, avoiding off-target effects, and ensuring the stability and persistence of miR-34a mimics in the body. Additionally, understanding the complex regulatory networks involving miR-34a and its interactions with other molecular pathways is crucial for optimizing therapeutic strategies.
