Are there therapeutic strategies targeting HIF-1α?
Given its pivotal role in cancer, HIF-1α is a potential target for cancer therapy. Strategies to inhibit HIF-1α include small molecules that prevent its stabilization, inhibitors of its dimerization with HIF-1β, and agents that block its transcriptional activity. Some therapeutic agents like topotecan and digoxin have shown promise in preclinical studies. However, the complexity of HIF-1α regulation and its involvement in normal physiological processes pose challenges for developing effective and safe inhibitors.
