HIF-1α contributes to tumor progression by promoting angiogenesis, which supplies the tumor with necessary nutrients and oxygen. It also enhances glycolysis, allowing cancer cells to generate energy even in low oxygen conditions. Furthermore, HIF-1α activation can lead to increased cell proliferation, migration, and invasion, thereby aiding in metastasis. Its role in altering the tumor microenvironment makes it a key player in cancer development and progression.
