What is Hypoxia Inducible Factor 1 Alpha (HIF-1α)?
Hypoxia Inducible Factor 1 Alpha (HIF-1α) is a transcription factor that plays a crucial role in the cellular response to low oxygen levels (hypoxia). It is part of the heterodimeric HIF-1 complex, which consists of HIF-1α and HIF-1β subunits. Under normal oxygen conditions, HIF-1α is degraded rapidly. However, under hypoxic conditions, it stabilizes and translocates to the nucleus where it activates the transcription of various genes involved in adaptation to hypoxia.
