Can Calcium Homeostasis be Targeted for Cancer Therapy?
Targeting calcium homeostasis presents a potential therapeutic strategy in cancer treatment. Drugs known as bisphosphonates are used to manage bone metastases and related hypercalcemia by inhibiting osteoclast-mediated bone resorption. Moreover, researchers are exploring the potential of targeting specific calcium channels and transporters that are upregulated in cancer cells. Modulating these channels may help to disrupt the abnormal calcium signaling pathways driving cancer progression.
