Can Mitochondrial Dysfunction be Targeted for Cancer Therapy?
Yes, targeting mitochondrial dysfunction holds promise for cancer therapy. Several strategies are being explored, including:
1. Mitochondrial Metabolism Inhibitors: Drugs that inhibit mitochondrial enzymes critical for cancer cell metabolism. 2. ROS Modulators: Agents that increase ROS to toxic levels to induce cancer cell death. 3. Mitochondrial Membrane Permeabilizers: Compounds that disrupt mitochondrial membranes to trigger apoptosis.
