What Are the Challenges in Studying Mitochondrial Dysfunction in Cancer?
Studying mitochondrial dysfunction in cancer presents several challenges:
1. Complexity: The mitochondrial genome is small but highly complex and interacts with the nuclear genome. 2. Heterogeneity: Mitochondrial dysfunction can vary significantly between different types of cancer and even within tumors. 3. Dynamic Nature: Mitochondria are highly dynamic and can rapidly change in response to cellular conditions. 4. Technical Limitations: Current technologies may not fully capture the nuances of mitochondrial function and dysfunction.
