How is Mitochondrial Dysfunction Detected in Cancer?
Mitochondrial dysfunction can be detected using various techniques such as:
1. Sequencing: Identifying mutations in mtDNA or nuclear genes associated with mitochondrial function. 2. Metabolic Profiling: Assessing changes in cellular metabolites indicative of altered mitochondrial activity. 3. Imaging: Using fluorescent dyes to visualize mitochondrial function and morphology. 4. Oxygen Consumption Rate (OCR) Measurements: Evaluating the efficiency of oxidative phosphorylation.
