Can Oxidative Biotransformation Affect Cancer Treatment?
Yes, oxidative biotransformation can significantly impact the efficacy and toxicity of cancer treatments. Many chemotherapeutic agents require activation through biotransformation, often mediated by CYPs. Variations in enzyme activity due to genetic polymorphisms or drug interactions can affect drug metabolism, leading to differences in treatment response and adverse effects. Understanding an individual’s biotransformation profile can aid in personalized medicine, optimizing drug dosing and reducing toxicity.
