Can Targeting Redox Balance be a Therapeutic Strategy?
Targeting redox balance is a promising therapeutic strategy in cancer treatment. By disrupting the redox homeostasis of cancer cells, it may be possible to selectively induce oxidative stress and cell death in cancer cells while sparing normal cells. Several approaches are under investigation, including the use of pro-oxidant therapies that increase ROS levels and the inhibition of antioxidant pathways. Drugs like buthionine sulfoximine (BSO), which depletes GSH, and APR-246, which reactivates mutant p53 and promotes ROS generation, are examples of such strategies.