What are the Consequences of Imbalanced Redox in Cancer?
Imbalanced redox can have several consequences for cancer progression. Elevated ROS levels can promote genomic instability, leading to mutations that drive cancer development. ROS can also activate signaling pathways such as NF-kB and MAPK, which support cell survival, proliferation, and metastasis. However, excessive ROS can also trigger cell death pathways, such as apoptosis or ferroptosis, highlighting the need for a tightly regulated redox environment.
